I’m forgetting my analogy, how it worked. I just found that fascinating that there might be this kind of strength to this to maybe not having as effective of a glutathione production system. A simple a way to understand if you’re mouth-breathing or breathing poorly, is if your hands are routinely cold. Ari Whitten: Yeah, absolutely. I file everything away mentally about how everything makes me feel. Supplements are simply a way to Spot Clean your Fast COMT. Dr. Ben Lynch: I like where you’re going with this, and some of what you said is right on and the example of Curcumin, Curcumin will slow the CRMT gene down. It’s a conductor, so it has to be present. That is one problem is Folic acid is everywhere and pervasive in the environment, and I strongly believe that no one should be eating folic acid because it’s not just the MTHFR gene that’s a problem, it’s all the other Folate genes too. But I want people to understand that if you’re born dirty with these genes, you’re not locked into a problem, they’re just already born dirty. You don’t want to overwork your genes that are dirty, and you want to help them out, you want to lend a hand. I remember when I was in the grocery store with my boys years ago. I would like to meet with you. And there’s just there’s so much of this thinking out there on genes that’s like, “I have this gene and therefore I have this condition. So I really enjoyed the book and I really enjoyed that conversation, and I hope you did too. But anyway, if you lived in an area that had malaria and you had MTHFR, you survived. That’s what I call the ABCs of clean genes – A is Avoidance. When you feel better, your hands are warm again – pick up the book, start reading where you left off. I was like, “Wow,” and so if you give something with the belief that it’s going to only help, you are creating bias. This has been a brilliant discussion and I am a big fan of your work and this was a lot of fun to connect with you in person and have this conversation, and I think people are going to love it. I’m putting a lot of pressure on the people behind me, I know. So a lot of people have a problem or a symptom they want to swallow something for that. Every other animal’s outside and they are grazing, they are foraging, they are harvesting, they are storing. Marjanovic, J.A., Li, Z., Stojanovic, A., Du, X. J. Biol. Allan (6:25): There are hundreds of thousands of genes throughout our body and they’re all going to respond differently. There’s only a time when you look back and wish you had started earlier. I found that fascinating, and I think it’s really counterintuitive for a book on dirty genes to have the author saying … Right before this, you had said genetic testing you don’t really need to go do genetic testing, and then if you do genetic testing and you have that inkling to say, “What are my problem genes? I almost dedicated the book to… It was going to say something along the lines, “This book is dedicated to those who read and actually implement what they read.” Because you can read all you want, but if you don’t actually implement, no book is going to serve you and you’re going to be complaining that the book didn’t help you out. Find out! And it’s very, very important – don’t get me wrong – but there are six others that I think also are. It has all the vitamins and minerals that a growing body needs, and now we’re eating that and /or we’re feeding that to our children. I’d like to keep in touch and your resiliency thing is a good point to get out there too, push that model, and I think it’s a great one. So it’s pretty simple, that folate comes from green, leafy vegetables – the darker the green, the more folate typically. I didn’t pick snips, I didn’t pick mutations, I didn’t pick variations. NOS3, also known as eNOS, produces nitric oxide in our blood vessels, which helps vasodilation and mediates formation of blood vessels, and promotes blood clotting by activating platelets ().NOS3 is associated with these diseases: I work hard on that, because I’m vehemently against it. Ari Whitten: Yeah and one more point to add to this, it’s just extending this line of thinking just out of curiosity I had looked earlier today to see if I could see any link between GST and GPX genes and chronic fatigue syndrome specifically whereas Robert Naviaux research indicates the cell danger response is likely playing a big role in that syndrome. I can’t believe that the vitamin manufacturers are allowed to feed us this stuff. There’s so much emphasis on breast cancer, and there should be, but the number one killer actually in women is cardiovascular disease. It’s sold everywhere and it’s been translated into 11 languages. I don’t think they have anything planned. There are benefits to having a dirty NOS3 gene that we’ve also talked about in the book, it’s really important for cardiovascular disease. It has to be transformed into something that’s usable, and that requires genes. Humans, on the other hand – very, very slow. Dr. Ben Lynch: I would say nine times out of 10 it will be Synthetic Folic acid if it just says Folate. In fact, the last one I did was on how to put together a fraud investigation. Our genes are responsive for that, but they’re responding to the things that we are providing them. Dr. Ben Lynch: Well done, well done. B is Breathe. So I’m going to be getting the real education, I’ve got all the science there and all the citations and I have the clinical evidence to back it up too. Let it sit there for two weeks, three weeks, and focus on your breathing. Genes do work, and if you give your genes healthy food, they can do healthy work. And sometimes I will walk by a bag of chips or a 4 pack of alcoholic apple cider. I actually did find that there is a GST gene SNP that is linked to chronic fatigue syndrome, so I found that fascinating as well. And that’s where I wanted to start this discussion today. That was… we learned that it was bad, and now we’ve got Wi-Fi and EMF all over us, so who knows how that happened. Some of us have to be more protected and more aware of the susceptible problems, and people know that PCs are susceptible to viruses. I know it sounds not like these are big changes, and they’re not, which is the cool thing, but the impact you will feel is massive. Some days we’re more tired, some days we’re full of energy, other days we’re grumpy and don’t really want to meet anybody, other days we want to go party hard. So they’re getting it, and they make their own choices. What that means is, you have low levels of folate in your brain. I had Dr. John Day on the show for episode 272. Dr. Ben Lynch: Yeah, thank you, and I thank her a lot for that too because anytime I wrote something, because I would write the chapters and send it to her and she’d just get on the phone and is like, “I don’t get this.” She goes mad at me and she goes, “What are you talking about?” So it was great. I said, “Are you serious?” And he goes, “Yeah, we need a 30-day program.” I said this is a program to help people clean their genes for the rest of their life; this is not a 30-day thing. I just tested my arsenic levels years ago when I was doing landscape construction and my arsenic levels were high, really high because I was cutting treated lumber all the time, and so I was inhaling and had arsenic all over my hands. It’s literally gumming up your genetics and your whole body. So I do hope that you’re thinking about this, that you’re considering this. And one of the concepts that came up was how when someone’s trying to teach you how to do an online business, most of the people that were successful at that are actually just selling to other people that want to run online businesses. Human(4846) Summary: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. After you get through with this episode, you can go to 40PlusFitnessPodcast.com/272 and listen to Dr. Day. The title of your new book is called Dirty Genes, so what the heck are dirty genes? I talked with him all the time and he’s a phenomenal individual and author of the paper. Dr. Ben Lynch: Yeah, thanks for bringing that up. If it’s too much, or too little, it’s the same thing with a supplement. For me, I kind of resonate and I look at things and I will pretend that I’d taken that supplement or I’ve eaten that food, and then I look at myself about 20, 30 minutes in the future and see if that was going to help me. They’re still kids; they bounce back faster than adults do, but they still experience repercussions – performance in soccer games goes down, their moods get altered, their noses get messed up, their faces get messed up, they do worse in school. When I hear people speaking about it or writing about it, almost always I find myself not really agreeing with the paradigm and a lot of the information that they’re presenting. Dr. Ben Lynch: Boom. Because if you understand how your body works and why it’s important to breathe properly and why it’s important to eat certain foods and avoid certain foods at certain times; even healthy food you need to avoid at certain times, and I explain why – it will really make sense to you, especially when you apply it and you’re aware of the changes. Getting back to some of these genes, I guess sticking with MTHFR, what are some of the practical steps that someone can take to help address that issue? I think, especially, as we get into a lot of the genetic engineering type of stuff, I think that we are going to find …. So you’re right, it needs a paradigm shift. Yeah, because you won’t get better, you’ll only get frustrated and doctor after doctor, person after person, I’ve talked to says genetic testing was the dumbest thing I ever did. Dr. Ben Lynch: No, no, the simple answer is no. Your StrateGene report will still provide Test to see if your NOS3 is dirty here. So you do it for as long as you need to, and you do it in a way that is not overwhelming to you. It’s your choices that are doing that. Again, it’s in New London, Connecticut, July 20th to the 22nd. I’ll give you an example. Our inputs for our own body are again just like the keys on a keyboard. Oh, I’m next.” And now it’s totally the opposite. Instead of stripping the nutrients anymore from the grains, we’re going to synthesize a nutrient that looks very close to the body’s natural form of folate.” And they did a great job. So that is what we want to have in our blood, that type of Folate, and our MTHFR gene makes that for us. Glad to hear that. It’s so close to the natural form of folate that is recognized by the human body, that it does get well absorbed and it does bind to folate receptors, and it does get bound to the transportation systems in our bodies to carry the folate around. Dr. Lynch (41:29): Yeah, but it’s great that it’s so available. It’s like, “Oh God, what was our family history? Ari Whitten: Yeah, I love that. What made me better was changing my environment and getting rid of chemicals and eating more salad. He recommends a 2 week "soak and scrub", during which time a person can function on "cleaning" all of their genes - focusing on diet, exercise, sleep, stress relief, and avoidance of toxins to the extent possible. Ari Whitten: They view it as like take it and you should be on it indefinitely. Dr. Ben Lynch: Yeah, oh God, and I fought and I fought and they fought back and I fought and they fought back and because-. Glutathione is just coming along and trying to defeat the purpose of the chemotherapy so that why having a glutathione problem for chemo is not good. It’s kind of a tag team, these two. I’ll be arriving I think on the 19th. Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7. The NOS3 gene codes for the enzyme Nitric Acid Synthase 3, which naturally facilitates the production of NO. So, a little bit of a learning curve to get back into PowerPoint. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Dad, how do you walk by those without any issue?” I said, because I put myself one hour into the future, after I’ve enjoyed them, and I realize that they’re going to make me super tired, have a headache, they’re going make the yeast overgrow and I’ll be battling that for probably two months. So if you’re an individual and you’re consuming folic acid and you have symptoms, the first thing you need to do is stop taking the folic acid. If you’re on the fence about hiring a coach, please do give me a call. And it’s been great that I’ve done that. When I called them born dirty, I mean that they can make you more susceptible to having symptoms. We don’t always make the right decision for ourselves, but there’s a cost-benefit to pretty much everything we do. Then we've got NOS3, sometimes called NOS3. NOS3, the gene that can create heart issues. Ari Whitten: Very cool. My next book is going to be on preconception and prenatal care. If you have MTHFR, that’s born dirty, meaning it works more slowly because we attribute slow as being bad, and my MTHFR gene works about 30% compared to the person who has no MTHFR polymorphism. Let’s get our vitamins that way.” And so they get the multivitamin with the folic acid. I am a sucker for chips and I realize that the more stressed I am, the more junk food I eat, so I do a really pretty good job, not fantastic, a pretty good job for reigning in my stress. But we also have neuro transmitters in our brain fire because of that, where we get stressed out and we get a flood of norepinephrine probably. 5: HUMAN PROTEIN ATLAS INFORMATION i. ‘A dirty gene is born dirty via a SNP or becomes dirty from exposure to mold, chemicals or infection, The dirt impacts the ability of the gene to function properly.’ ‘A dirty gene is a gene that needs a Soak and Scrub’ And – my favorite definition of a Dirty Gene – as it is so clear and concise: (2005) Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study. What are some of the strengths and I guess the … Well, let’s talk about some the weaknesses of the MTHFR not having have the most optimal SNP. So, we combine these two because I was just doing GST or GPX alone, and I could not write the chapter effectively. But there are seven, and you call them the “Super Seven”. NOS3, the gene that can create heart issues NOS3 affects your production of nitric oxide, which is a major factor in heart health, affecting such processes as blood flow and blood vessel formation. I’m just trying to prevent you from all being frustrated and you’re going to … You will get way more benefit of dirty genes and your whole life and if you do the fundamentals first, and then you tweak your genes. Dr. Ben Lynch: Yes, stop, stop. If you’re overworked, you get tired and stressed out and you don’t perform as well and you start making mistakes, same with your genes, and it’s that simple. Super itchy episode, you have the 4-week clean gene protocol above ” right... S going to go through over the course of four weeks and,! Really pleasantly surprised at your work, and this one ’ s something you do is better keep. And some other foods as well, you have the 4-week clean gene protocol pretty I. 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